Punching Holes in an Enzyme

Manufacturing Features in Cutting Shapes and Punching Holes in Sheet Metal

By examining sheet metal parts it is rather evident that each sheet metal shape has its own manufacturing procedure. There are several manufacturing devices behind each procedure. This means that each shape can be divided into manufacturing features, which consist of shapes of sheet metal and their manufacturing methods. When creating rules and structures for manufacturing features, it is possi...

Signaling beyond Punching Holes: Modulation of Cellular Responses by Vibrio cholerae Cytolysin

Pore-forming toxins (PFTs) are a distinct class of membrane-damaging cytolytic proteins that contribute significantly towards the virulence processes employed by various pathogenic bacteria. Vibrio cholerae cytolysin (VCC) is a prominent member of the beta-barrel PFT (beta-PFT) family. It is secreted by most of the pathogenic strains of the intestinal pathogen V. cholerae. Owing to its potent m...

Double-punching PMBL

Success stories in looking for effective strategies against cancer often have their roots in pathology. In case of primary mediastinal B-cell lymphoma (PMBL), this was likely the recognition as a distinct subtype of diffuse large B-cell lymphoma (DLBCL) in the early 80s [1, 2]. Initially a controversial entity, over the last 30 years, it has become clear that PMBL differs in pathogenesis, clini...

Meniscal shear stress for punching.

AIM Experimental determination of the shear stress for punching meniscal tissue. METHODS Meniscectomy (surgical treatment of a lesion of one of the menisci) is the most frequently performed arthroscopic procedure. The performance of a meniscectomy is not optimal with the currently available instruments. To design new instruments, the punching force of meniscal tissue is an important parameter...

[Human factors in card punching operation].